Endocrine Abstracts

Background: Maternal free testosterone (FT) increases during 3rd trimester pregnancy and FT levels are higher in women with polycystic ovary syndrome (PCOS) compared to controls. Fetal exposure to maternal FT during 3rd trimester was associated with lower weight, length and shorter abdominal circumference at birth, in boys. Furthermore, lower birth weight has been related to higher abdominal fat mass in young children.Aim: To examine associations between...

Background: Perfluoroalkyl substances (PFAS) are endocrine disrupting chemicals, with elimination half-lives ranging from four to eight years. Experimental studies found PFAS able to interfere with thyroid hormone-binding proteins. During the first 20 weeks of gestation (GW), the fetus is reliant on placental transfer of maternal thyroid hormones, mainly free thyroxine (FT4). However, previous studies investigating associations between exposure to PFAS and thyroid hormone stat...

Background: Prolactin is associated with metabolic risk inside and outside of pregnancy. Maternal prolactin levels could be associated with offspring body composition.Aim: To investigate if maternal prolactin-levels were linked to offspring body composition at seven years of age.Design: Prospective observational cohort study (the Odense Child Cohort).Methods: Maternal fasting blood samples were assessed durin...

Background: Non-functioning pituitary adenomas (NFPAs) necessitate prolonged clinical, biochemical and radiological observation, constituting a significant burden in terms of medical resources and societal costs. Reliable biomarkers associated with aggressiveness and recurrence of NFPAs are lacking. As the growth of tumor remnants is highly variable, molecular markers that can predict growth potential and tumor behavior are necessary.Aim: To identify tar...

Context: Assessment of disease control in acromegaly depends on GH and IGF-I, but discordant values frequently occur. Further, the role of OGTT-suppressed GH (GHnadir) in somatostatin analogue (SA) treated patients is debated.Objective: To evaluate the effect of targeting either IGF-I or GH during SA treatment.Design: A randomized, investigator-initiated, multicentre trial.Patients and methods: 84 ...

Objective: The beneficial effects of testosterone treatment (TT) in men with low normal testosterone levels are debated. Chemokine levels have not previously been evaluated during TT in combination with strength training (ST).Design: A randomized, double-blinded, placebo-controlled study of 6 months TT (gel) in 54 men aged 60–78 years with bioavailable testosterone (BioT) <7.3 nmol/l and waist circumference >94 cm randomized to TT (50–1...

Introduction: Maternal thyroid function in early pregnancy is crucial for fetal neural development. Early offspring language acquisition is an important indicator of fetal neural development and a predictor of future cognitive development. We aimed to investigate how the mother’s thyroid function and the presence of thyroid autoimmunity in early pregnancy are associated with offspring’s language acquisition at the age of 12-37 months.Methods: T...

Background: The risk of type 2 diabetes (T2D) in PCOS is associated with BMI, but prospective data regarding risk of T2D in PCOS are limited. We investigated prospective risk of T2D in Nordic women with PCOS compared to controls.Methods: National register-based study in women with PCOS and age-matched controls originating from Denmark (PCOS Denmark, (n=27,016, controls, (n=133,994), Finland (PCOS Finland, (n=20,467, controls, (...

Background: Synthetic glucocorticoid exposure in late pregnancy may be associated with higher blood pressure in offspring. We hypothesized that endogenous cortisol in pregnancy relates to offspring blood pressure (OBP).Objective: To investigate associations between maternal cortisol status in 3rd trimester pregnancy and OBP.Methods: We included 1,317 mother-child pairs from Odense Child Cohort (OCC), an observational prospective co...

Introduction: Myopathy is a known and dreaded adverse effect of pharmacological glucocorticoid (GC) treatment, but its impact on daily physical activity is not known.Aim: To measure spontaneous physical activity and musculoskeletal function in patients shortly after planned cessation of long-term (>12 weeks) prednisolone treatment.Patients and methods: Baseline data from an ongoing nation-wide prospective study (DOUBLE EDGE &#1...